Located on the banks of the Ohio River in Clarksville, Indiana at I-65, exit 0, is the Falls of the Ohio State Park. The 390-million-year-old fossil beds are among the largest, naturally exposed, Devonian fossil beds in the world. The park features a spectacular Interpretive Center (now closed for renovation until fall, 2015) overlooking the fossil beds containing an exhibit gallery and video presentation. The Interpretive Center is open year round, except Thanksgiving and Christmas day.

The "Falls" was originally a series of rapids allowing the Ohio River to drop 26 feet over a distance of two and a half miles. This was the only navigational hazard over the 981 mile-length river formed by rock outcrops. Today much of the original falls have been flooded behind the McAlpine dam.